Contact Pharmaceutical Sciences

Chair: Christine Birnie
Email: cbirnie@sjfc.edu
Office: WEGPHR 317
Phone: (585) 385-7202

Research in the Pharmaceutical Sciences

Contributions to the Knowledge of Science

The Department of Pharmaceutical Sciences is continuously successful in obtaining external funding to support the research and scholarship of the faculty. Recently, two new laboratories have been constructed, one devoted to research in molecular pharmacology and one to pharmaceutical formulation studies. The labs are equipped with modern instrumentation, including:

Pharmaceutical Formulations and Drug Stability

Molecular Pharmacology and Cell Biology

  • High performance liquid chromatography (HPLC) (Shimadzu)
  • UV/VIS spectroscopy (Cary 50)
  • Thermogravimetric Analysis (TGA) (TA Instruments)
  • Differential Scanning Calorimeter (DSC) (TA Instruments)
  • X-Ray Diffractometer (Bruker)
  • Moisture Sorption/Desorption Analyzer (TA Instruments)
  • Particle Size Analysis and Processing (Horiba)
  • USP Dissolution apparatus with Optic Fibers (Distek)
  • USP Dissolution apparatus (Vankel)
  • Incubator (Fisher Scientific)
  • Stability Chambers (Thermo Scientific)
  • Natoli Tablet Press
  • Rotary (ten-station) Tablet Press (SMI Piccola)
  • Diosna Wet Granulator
  • Retsch Ball Mill
  • Rotary Solvent Evaporator (buchi)
  • Twin Shell Dry Blender (PK)
  • Quadro Comil
  • Tap Density Apparatus (Varian)
  • Bulk Density Apparatus (Scott Volumeter)
  • Sonic Sifter (Advantech)
  • Sieve Shaker (Rotap)
  • Tablet Friabilator (Varian)
  • Tablet Hardness Tester (Varian)
  • Tablet Disintegration Tester (Varian)
  • True Density Pycnometer (Micromeritics)
  • Buchi Spray Dryer
  • VirTis Lyophilizer (SP Scientific)
  • pH Meter (mettler Toledo)
  • Heratherm Oven (Thermo Scientific)
  • Incubator Shaker (New Brunswick Scientific)
  • Unuator (CITO)
  • Ointment Mill (EXAKT)
  • Milli-Q Purified Water System (Millipore)
  • Real-time automated PCR
  • Electrophoresis
  • Zeiss fluorescence microscope
  • Radioisotope-based protein binding assays
  • Cell culture facilities and CO2 incubators
  • Airstream Class II biosafety hood
  • Refrigerated centrifuges
  • Low temperature (-80° C and liquid N2) storage
  • SpectraMax UV.Vis and Fluor microplate reader
  • Kodak imaging system
  • VersaDoc imaging system
  • Brandel cell harvester
  • Autoclave (Fisher Scientific)
  • Liquid Scintillation Analyzer (Perkin Elmer)

Additional facilities, such as gas chromatography-mass spectrometry, NMR, ultracentrifuge, cell culture facilities, small animal vivarium, and a cold storage room are available through collaboration with the departments of Biology and Chemistry.

Numerous opportunities exist for student-directed research, including independent study, advanced practice rotations in research and/or academia, laboratory teaching assistants, and the Science Scholars Program in Biology and Chemistry. The following areas represent the variety of research being conducted in the Department:

  • Scholarship of Teaching and Learning Related to Cultural Competency (Mathews)

    • Mathews JL, Parkhill AL, Schlehofer DA, Starr MJ, Barnett S. Role-reversal Exercise with Deaf Strong Hospital to Teach Communication Competency and Cultural Awareness. American Journal of Pharmaceutical Education 75(3):53-63 (2011)[PMID: 21655407]
  • Regulation of Gene Expression by Mu Opioid Receptors (Parkhill)

    • Bidlack JM, Khimich M, Parkhill AL, Sumagin S, Sun B, Tipton CM. Opioid Receptors and Signaling on Cells from the Immune System. Journal of Neuroimmune Pharmacology 1: 260-269 (2006)[PMID: 18040803]
  • Mechanisms of Chronic Inflammatory Disease (Sapinoro)

    • Sapinoro R, Rodrigo S, Schlesinger J, Dewhurst S. Fc receptor mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells. Virology 373(2):274-86 (2008)[PMID: 18991979]
  • Environmental Causes of Neurodegenerative Disease (Lull)

    • Lull ME, Block ML. Microglial activation and chronic neurodegeneration. Neurotherapeutics 7: 354-365 (2010)[PMID: 20880500]
    • Levesque S, Taetzsch T, Lull ME, Stadler K, Kodavanti U, Johnson J, Kodavanti P, Block ML. Diesel exhaust activates and primes microglia: air pollution and neuroinflammation. Environmental Health Perspectives Epub ahead of print (2011)[PMID: 19926406]
  • Classroom and Laboratory Teaching Methods in Physical Pharmacy (Birnie)

    • Zhao F, Birnie C, Budukh P. Punch or Tamp – Capsule Compounding in Pharmaceutics Lab Courses. American Journal of Pharmaceutical Education 74(5):48 (2010)[abstract]
    • Zhao F, Budukh P, Birnie C. Bridging Drug Physicochemical Properties With Formulation Design – A Two-Semester Series of Student Projects on Pharmaceutics. American Journal of Pharmaceutical Education, 73(4):29 (2009)[abstract]
  • Preformulation and Formulation Development (Zhao)

    • Prohotsky D, Zhao F. A survey of top 200 drugs – Inconsistent practice of drug strength expression for drugs containing salt forms. Journal of Pharmaceutical Sciences Epub ahead of print (2011)[PMID: 21905029]
    • Kaltenbach M, Hutchinson D, Bollinger J, Zhao F. Stability of diluted adenosine solutions in IV bags stored at two different temperatures. American Journal of Health Systems Pharmacists 68:1533-1536 (2011)[PMID: 21817085]
  • Drug Degradation in Veterinary Dosage Forms (Birnie)

    • Pignato A, Pankaskie M, Birnie C. Stability of Methimazole in Poloxamer Lecithin Organogel to Determine Beyond-Use Date. International Journal of Pharmaceutical Compounding 14(6):522-5 (2010)[abstract]

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